In such cases, the lymph node should return to its usual size once the infection has cleared. Infectious causesĪ swollen lymph node usually occurs as a result of infection. The treatment options for swollen lymph nodes depend on the underlying cause. In rare cases, a chemotherapy drug known as granulocyte colony stimulating factor may also cause swelling of the lymph nodes. sulfonamides, such as sulfasalazine (Azulfidine), a disease-modifying anti-rheumatic drug (DMARD) used to treat psoriatic arthritis and other chronic inflammatory conditions.quinidine (Quinidex), used for some irregular heartbeats.phenytoin (Dilantin) and primidone (Mysoline), used to manage seizures.
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